The singer/songwriter, who is battling ongoing vocal problems, has debuted Born And Raised at the top of the countdown, thanks to first-week sales of 219,000.
It's Mayer's third number one and his first chart-topper since Battle Studies in 2009.
Hear Mayer talk about his new album:
Adele and Carrie Underwood stand firm on the new chart at two and three with 21 and Blown Away, respectively, while Slash's Apocalyptic Love debuts at four and One Direction's Up All Night jumps back into the top five at five.
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